JS laboratory

The JS lab is exploring all aspects of gut microbiota and host-microbiome interactions, particularly in the context of metabolic disease.

 

We develop and implement a generalized workflow that enables high-throughput characterization of gut microbiota interactions under diverse environmental conditions. The intestinal microbiota plays a crucial role in preventing the overgrowth of bacterial pathogens, and studying their interactions under various environmental conditions could reveal species and communities with robust inhibitory potential, as well as identify the molecular mechanisms of inhibition. ​​

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The JS lab is also investigating how host-microbiota interactions contribute to the development of metabolic diseases. We are interested in identifying and further characterizing how key gut microbiota-derived metabolites impact distal organs through the circulation, and how tissue-derived metabolites affect gut microbiota homeostasis and functioning.