JS laboratory

The JS lab develops and implements a generalized workflow that enables high-throughput characterization of the pathogens-microbiome interactions under diverse environmental conditions to design robust anti-pathogen consortia. We are particularly interested in the human microbiome since it has the most direct and important implications for human health. The intestinal microbiota plays a key role in preventing the overgrowth of pathogens, and studying their interactions under various environmental conditions could reveal species and communities with robust inhibitory potential and identify molecular mechanisms of inhibition. 

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In addition, pathogens could persistently colonize the gut for long timescales, posing a risk factor for infections. Our lab investigates how interactions with commensal microbes affect pathogens’ adaptation to perturbations. Studying the adaptation of pathogens is essential to develop new combat strategies and prevent the emergence of more virulent or resistant strains, and also aid the design of microbial consortia with a more sustainable inhibitory effect.​

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The JS lab is also interested in host-microbe interactions and metabolic diseases. We study why immunocompromised people are more susceptible to infections with bacterial pathogens, and hope to develop novel treatment approaches for these individuals, e.g. using defined microbial therapeutics.